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To evaluate the diagnostic accuracy of CAP for detecting hepatic steatosis, areas under the receiver operating characteristic curves (AUROC) were computed, and were compared using the method of Delong et?al. [30]. To determine the ability of the CAP to differentiate between individual steatosis grades, we also calculated the AUROC between pairs of steatosis grades. The efficiency of both LS value and CAP value predicting the fibrosis stage and steatosis grade was evaluated for the entire population. Cut-off values, sensitivities, specificities, positive predictive values (PPV) and negative predictive values (NPV) were computed for CAP after maximizing the Youden index (sensitivity?+?specificity-1). Hazard ratios and the corresponding 95% confidence http://www.selleckchem.com/products/Aloxistatin.html interval (CI) are also indicated. A P value 25?kg/m2) according to the new BMI criteria for Asians by World Health Organization [31]. The main aetiologies of CLD were NAFLD (n?=?56, 41.5%) and chronic viral hepatitis including chronic hepatitis B (n?=?47, 34.8%) and C (n?=?12, 8.9%). Other http://www.selleckchem.com/products/DMXAA(ASA404).html aetiologies were autoimmune hepatitis (n?=?8) and primary biliary cirrhosis http://en.wikipedia.org/wiki/Resveratrol (n?=?12). The steatosis grade was S0 in 42 (31.1%) patients, S1 in 59 (43.7%), S2 in 25 (18.5%), and S3 in 9 (6.7%) respectively. The median LS value was 10.9?kPa. The AUROCs of LS value to detect ��F2, ��F3, and F4 fibrosis stages were 0.885 (95% CI, 0.807�C0.951), 0.915 (95% CI, 0.882�C0.930) and 0.957 (95% CI, 0.939�C0.980) respectively. The optimal LS cut-off values were 7.9?kPa for �� F2, 9.1?kPa for �� F3 and 15.0?kPa for F4, which maximized Youden index (sensitivity?+?specificity-1). The median CAP value in our cohort was 256?dB/m (range, 149�C400). The median CAP values for patients with S0, S1, S2 and S3 steatosis were 217?dB/m (range, 149�C288), 271?dB/m(range, 150�C377), 336?dB/m(range, 234�C400) and 335?dB/m (range, 230�C366) respectively. CAP was significantly different between S0 and S1 steatosis, and S1 and S2 steatosis (P?