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Longer diabetes duration was also associated with increased metastasis risk. ""To examine the performance of T2-weighted https://www.selleckchem.com/products/Fludarabine(Fludara).html (T2W) and diffusion-weighted (DW) magnetic resonance imaging (MRI) for detecting the index tumour in patients with prostate cancer and to examine the agreement between MRI and histology when assessing tumour volume (TV) and overall tumour burden. The study included 199 consecutive patients with biopsy confirmed prostate cancer randomised to MRI before radical prostatectomy from December 2009 to July 2012. MRI-detected tumours (MRTs) were ranked from 1 to 3 according to decreasing volume and were compared with histologically detected tumours (HTs) ranked from 1 to 3, with HT 1 = index tumour. Whole-mount section histology was used as a reference standard. The TVs of true-positive MRTs (MRTVs 1�C3) were compared with the TVs found by histology (HTVs 1�C3). All tumours were registered on a 30-sector map and by classifying each sector as positive/negative, the rate of true-positive and -negative sectors was calculated. The detection rate for the HT 1 (index tumour) was 92%; HT 2, 45%; and HT 3, 37%. The MRTV 1�C3 vs the HTV 1�C3 were 2.8?mL vs 4.0?mL (index tumour, P https://www.selleckchem.com/products/Nolvadex.html and -negative sectors was 50% and 88%, �� = 0.39. A combination of T2W and DW MRI detects the index tumour in 92% of cases, although MRI underestimates both TV and tumour burden compared with histology. Multifocality is present in 56�C87% of patients with biopsy confirmed prostate cancer [1, 2]. When using MRI, the detection rate of cancer foci depends on tumour volume (TV), the Gleason score, and the zonal location [3, 4]. Most studies have focused on the overall detection rate, and have stratified detection according to TV group using the histological TV (HTV) as a reference [5, 6]. MRI studies have rarely reported on individual tumours. Previous studies have shown https://en.wikipedia.org/wiki/Chlormezanone that the largest tumour usually yields the highest Gleason score and contributes to extraprostatic extension (EPE) and positive surgical margins [7-10]. In 2010, a Consensus Conference organised by the International Society of Urological Pathology (ISUP) suggested that the definition of the index tumour should be related to the clinical context in the following order of priority: EPE, then Gleason score, then TV. This means that a smaller tumour with an EPE or a higher Gleason score would be defined as the index tumour despite the presence of a larger tumour [11]. The aims of the present study were to examine the performance of T2-weighted (T2W) and diffusion-weighted (DW) MRI for detecting the index tumour, and to examine the agreement between MRI and histology for assessing TV and overall tumour burden.