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Pretransplant flow cytometric and complement dependent cytotoxicity (CDC)-crossmatching was performed in all recipients. http://www.selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html Transplantation was not performed in case of any positive crossmatch result. Donor specific antibodies (DSA) were not measured routinely. The common immunosuppressive regimen consisted of a calcineurin-inhibitor (CNI; cyclosporine or tacrolimus), steroids and mycophenolate mofetil (MMF) completed by induction therapy using an interleukin (IL-)2-receptor-antagonist (Basiliximab, Simulect?; Novartis International AG, Basel, Switzerland) 20?mg intraoperatively and on postoperative day 4. Patients with PRA levels higher than 30% received perioperative plasmapheresis which was started preoperatively and continued daily until the 4th postoperative day in combination with induction therapy with anti-thymocyte globulin (ATG, 1.5?mg/kg). Methylprednisolone was administered during surgery (500?mg) with progressive tapering to 20?mg/day within the 8th postoperative day. Cyclosporine was started 6�C12?h after transplantation and adjusted to obtain trough blood levels of 350�C450?ng/ml. Tacrolimus was started 6�C12?h after surgery and increased to achieve tacrolimus trough levels of 8�C11?ng/ml. MMF was administered 2000?mg/day. Early surveillance of kidney function was obtained by daily monitoring of diuresis, creatinine http://www.selleck.cn/products/incb024360.html serum levels and color-coded doppler ultrasound. Renal graft did not undergo scheduled surveillance biopsies unless rejection was assumed. Renal allograft rejection in this study was defined by any episode resulting in an increase in immunosuppressive therapy. Delayed graft function (DGF) was defined as postoperative need for dialysis at least one session until the 7th postoperative day. Primary nonfunction (PNF) was defined as need for dialysis for equal or more than 4?weeks http://www.selleckchem.com/products/bmn-673.html after transplantation. The follow up was complete for all patients at an average follow up time of 64?��?30?months (range: 16�C115?months) by December 31st, 2009. Graft and patient survival of the two groups were calculated by the Kaplan�CMeier method and compared using the log rank test. The two groups were compared using Student��s t-test and Kruskal�CWallis test. Variables are presented as mean?��?standard deviation or median (minimum �C maximum range). A value of P?