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This discrepancy may have arisen due to differences in study design; patients attending follow-up clinics may not be representative http://www.selleck.cn/products/Bleomycin-sulfate.html of the patients with acute or recent DVT and may be biased by an increased proportion of patients with a recent diagnosis of DVT or with complications of either PTS or recurrent VTE. Other observational studies reporting GCS use throughout follow-up reported lower adherence rates with 30�C50% reporting regular GCS use and http://www.selleckchem.com/products/Rapamycin.html of GCS. It may be possible to identify those most likely to benefit from interventional approaches to DVT management, such as catheter-directed thrombolysis. Limitations of our study are the incomplete data for the Villalta scale, which was only evaluated at study enrolment from January 2010. There was variability in the timing of initial Villalta assessment; to facilitate recruitment we allowed participants to enrol up to 1?month following DVT diagnosis. However, there was no significant http://www.selleckchem.com/products/MG132.html difference in timing of this assessment between those who did and those who did not develop PTS. It would be interesting to evaluate Villalta scale sequentially from presentation to determine the optimal time point for prediction of PTS. This would determine whether presenting symptom severity is predictive of later PTS or whether it is the persistence of symptoms following initiation of anticoagulation that is associated with risk of PTS. In comparison with previous studies, the duration of follow-up was relatively short at a median of 11?months. However, previous studies have demonstrated that PTS will manifest in the majority within 12?months of DVT (Prandoni et?al, 1997; Roumen-Klappe et?al, 2005). Despite the short duration of follow-up, we had a high proportion of PTS in our cohort with a cumulative incidence of 51��6%. Both the prevalence and distribution of severity of PTS at each time point was similar to previous observational studies utilizing the Villalta scale for PTS diagnosis (Kahn et?al, 2008b; Shbaklo et?al, 2009; Latella et?al, 2010). It is acknowledged that single assessment of the Villalta scale may overestimate PTS due to concomitant transient, unrelated leg problems contributing to symptom scores (Kahn et?al, 2009).