How much have all my problems taken out of me really?

I have felt a little more upbeat the past few days (except for a bad toothache, but no biggie).  I've tried to eat a little better and look to more positive things to help me through these tough times.  Well, yesterday when I was feeling good, I took a picture of myself for my facebook profile picture.  Then I was told by a couple of my closest friends that my picture looked bad... that I look like a balding cancer patient, weird-looking, etc.
That really hurts so I just changed my profile picture to a blank white box.  Really makes me wonder how I am looked at in real life then?  I know I've lost a lot of weight and lost some hair too, along with the sparkle I once had in my eyes, but I was feeling a little better about myself until this happened.  Then I had a falling out with a different friend at about the same time and I don't even know what I did wrong?  It all makes me feel very bad about myself and even more alone now.
My ex-wife destroyed my confidence and self-esteem.  Now every time it seems I try to start gaining a little back, someone is there to push me right back down.  Beyond frustrated. :(