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The primers also designed in a way to avoid nonspecific amplification of OCT4 pseudogenes, which have highly similar sequences to OCT4A. Furthermore, the identity of the amplified products was confirmed by direct DNA sequencing (data not shown). The relative expression of OCT4 spliced variants was compared between tumor and nontumor marginal tissues obtained from the same patients. Expression of GAPDH was used in all samples as an internal control, for normalization of probable sampling errors. Our data revealed that OCT4B1 is expressed in both tumor and nontumor samples of stomach. OCT4B1 expression http://www.selleckchem.com/products/Bortezomib.html was detected in 86.1% (31/36) of the tumor samples and 55.5% (20/36) of the marginal counterparts of the same tumors (Fig. 1a). However, the level of expression was much higher in the tumor samples compared to the apparent normal tissues obtained from the margin of same tumors (p http://www.selleckchem.com/products/gsk1120212-jtp-74057.html folds higher in the tumor group compared to that of nontumor (marginal) group (p http://www.selleck.cn/products/bgj398-nvp-bgj398.html and 44.5% (16/36) of nontumor ones. OCT4B showed a significant overexpression in the tumor group in comparison to the marginal samples (p