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The mean time to the NCS pattern of a fall in BP and heart was 15 minutes with a range of 13�C20 minutes. This group of patients was highly symptomatic and reported frequent clinical symptoms that were http://www.selleckchem.com/products/a-1155463.html suggestive of OI. Recurrent presyncope, syncope, orthostatic palpitations, exercise intolerance, and fatigue were the principal symptoms reported. Conclusion: NCS may coexist with POTS in a subgroup of patients suffering from OI. (PACE 2011; 34:549�C554) ""Chronic Chagas heart disease (ChHD) is associated with ventricular tachyarrhythmias and an increased risk of sudden cardiac death. Little is known about the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in this population. The objective of this study was to evaluate the efficacy of ICD in patients with ChHD and to identify predictors of mortality and appropriate ICD shocks. The cohort study included 65 patients with ChHD and ICD for primary and secondary prevention of sudden death. The Cox model was applied to evaluate the predictors of mortality, and survival was assessed by Kaplan-Meier analysis. The median age was 56 �� 11.9 years. The median follow-up was 40 �� 26.8 months. Among the patients 23 (36.5%) had appropriate shocks. A total of 13 (20%) patients died (6.1% of annual mortality rate), and there was no sudden death. In univariate Cox model, functional class IV (hazard ratio [HR] = 1.99; 95% confidence interval [CI], 1.05�C3.76; P = 0.034), primary prevention (HR = 0.29; http://www.selleck.cn/products/PD-0332991.html 95% CI, 0.09�C0.99; P = 0.048), http://www.selleckchem.com/products/cb-5083.html lower education (HR = 2.51; 95% CI, 1.05�C5.99; P = 0.038), and ejection fraction