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Using electronic medical records, PR and QT intervals, QRS duration, and heart rate were determined in 455 African Americans as part of the Vanderbilt Genome-Electronic Records Project and Northwestern University NUgene Project. We tested for an association between these ECG traits and >930K SNPs. We identified a total 36 novel associations with PR interval, QRS duration, QT interval, and heart rate at p http://www.selleckchem.com/PD-1-PD-L1.html with those previously identified in other populations. Five associations originally identified in other populations generalized with respect to statistical significance and direction of effect. A total of 43 associations have a consistent direction of http://www.selleckchem.com/products/Adriamycin.html effect with European and/or Asian populations. This work provides a catalogue of generalized versus nongeneralized associations, a necessary step in prioritizing GWAS-identified regions for further fine-mapping in diverse populations. ""The role of the lipoprotein-associated phospholipase A2 gene (PLA2G7) in atherosclerosis remains controversial. We investigated the frequency of single-nucleotide polymorphisms (SNPs) of PLA2G7 (rs16874954 and rs1051931) and their association with coronary artery disease (CAD) in a cohort of CAD patients (n= 806) and age-matched healthy controls (n= 482) in the Chinese Han population. The VF and FF genotype of rs16874954 was significantly more frequent in the CAD patients (13.5%) than in the controls (9.3%, P= 0.024). The association remained after adjustment for age, gender, body mass index, smoking status, history of diabetes, positive family history of CAD, high-density lipoprotein cholesterol, and triglyceride http://www.selleck.cn/products/MK-1775.html (OR = 1.922; 95% CI [1.146�C3.224]; P= 0.013). There was no significant difference in the frequency of any genotype of rs1051931 between the two groups. However, the frequency of the allele V379 was significantly greater in CAD patients with a history of myocardial infarction (MI) than in those without a history of MI (18.7% and 14.8%, P= 0.038). We conclude that there is significant association between the rs16874954 mutation and CAD in the Chinese Han population. The expression of rs1051931 variant in CAD patients may entail increased risk of MI. Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase (PAF-AH), is a member of the phospholipase A2 superfamily. It is a Ca2+-independent phospholipase that specifically hydrolyses phospholipid substrates with short and/or oxidized chains located on the sn-2 of the glycerin skeleton (Yanoshita et al., 1988; Stafforini et al., 1991). Lp-PLA2 is mostly secreted by macrophagocytes and monocytes, and approximately 70% of Lp-PLA2 binds to low-density lipoprotein (LDL) particles; the residual 30% binds to high-density lipoprotein (HDL) particles (Stafforini et al., 2003).