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In an additional multivariable model, we further adjusted for S-calcium, S-phosphate, S-creatinine and S-uric acid (all continuous) to take into account renal function that is associated with BP and 25(OH)D through the renin�Cangiotensin system (RAS). Of all these variables, only alcohol intake indicated deviation from a linear pattern. A P-value for nonlinearity was obtained by fitting a restricted cubic spline model with three knots at fixed percentiles (10%, 50%, 90%) and testing whether the coefficient of the cubic spline is equal to zero. Two-tailed significance values of P? https://en.wikipedia.org/wiki/Ketanserin as normotensive and confirmed hypertensive, are shown in Table?1. The study population was investigated at 70?years of age (range 69.5�C74.1). Plasma 25(OH)D concentrations were on average 3% lower in the participants with confirmed hypertension compared to the normotensive group. The prevalence of low 25(OH)D concentrations ( http://www.selleckchem.com/products/liproxstatin-1.html Table?2. http://www.selleckchem.com/products/midostaurin-pkc412.html Men with a 25(OH)D concentration 100?nmol?L?1), the prevalence of hypertension was nonsignificantly increased by 40%. However, this potential U-shaped relationship was not confirmed by a formal test for curvature of the association (P?=?0.39). In this community-based cross-sectional study of 70-year-old men, we observed a 3-fold higher prevalence of confirmed hypertension amongst men with low 25(OH)D concentrations (