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We used t-tests to compare bone outcomes between young adult (20-29 yrs) women and men, and linear regression to predict change in bone outcomes between 20 and 90 yrs. Bone area, which was 33% larger http://www.selleck.cn/products/LY294002.html in young men at both sites, changed similarly with age in women and men at the DT, but increased 22% more in men at the DR (p http://www.selleckchem.com/products/Adriamycin.html Disclosures: Heather Macdonald, None. 1238 High-Frequency, Low-Magnitude Mechanical Signals Do Not Prevent Bone Loss in the Absence of Muscle Activity.Sarah Manske*1, Steven Boyd1, Craig A. Good1, Ronald Zernicke2. 1University of Calgary, Canada, 2University of Michigan, USA Muscles play a role in transmitting mechanical stimuli to bone, and exogenous high-frequency, low-magnitude http://www.selleckchem.com/products/obeticholic-acid.html mechanical signals (LMMS) may promote bone adaptation by mimicking postural muscle activity. We hypothesized that daily exposure to LMMS would maintain bone structure despite muscle disuse following injection with botulinum toxin type A (BTX). Female 16 wk old BALB/c mice (N = 25) were assigned to (a) BTX + LMMS, (b) BTX + Sham, or (c) Sham. BTX mice were injected with BTX (20 ��L; 1 U/100 g body mass) into the posterior musculature of the left hindlimb. For 20 min/d, 5 d/wk, for 3 wk, all mice were anaesthetized and placed on a bed with the left leg strapped to a holder (tibiofemoral angle ?120��). Through the holder, the LMMS group received 45 Hz, 0.6 g acceleration with ?20 ��? without weight bearing. The sham groups received no mechanical input. The right leg served as an internal control. At baseline and 3 wk, muscle cross-sectional area (MCSA) and tibial bone properties (at metaphysis and diaphysis) were assessed with in vivo microCT (vivaCT40, Scanco Medical). Mice were sacrificed at 3 wk, and muscles were dissected and weighed.