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PNF was defined as a graft that did not achieve sufficient function to maintain the patient without regular dialysis from the time of transplantation. DGF was defined as the need for dialysis during the first week after transplantation, excluding those episodes of dialysis secondary to fluid overload or hyperkalemia during the first 24?h post-transplant. The http://www.selleckchem.com/products/Everolimus(RAD001).html indications for postoperative dialysis in the entire cohort were hyperkalemia (>6.6?mmol/l or http://www.selleck.cn/products/Bortezomib.html the patient��s death. The DDS was calculated for each kidney in both cohorts (DBD and DCD) and used to stratify the organs into four surrogate grades of organ quality (DDS grades A to D). Subsequently, univariate and multivariate analyses were performed to identify the relationship between DDS grades and clinical outcome in each cohort. In these analyses, linear regression models were fitted to each continuous variable, while logistic regression models were used for binary variables. Serum creatinine data were logarithmically transformed in the DCD cohort. Statistical analysis was performed using the SPSS.14 statistical package (SPSS inc, Chicago, IL, USA). T-test, Fisher��s exact test, and parametric and nonparametric Pearson��s correlation were used to compare continuous or categorical variables as appropriate, and graft and patient survival rates were calculated using the Kaplan�CMeier method. Two-tailed P-values http://www.selleckchem.com/products/PD-0332991.html an optimal kidney and 70 (42%) received a marginal organ. Recipient age was significantly different across DDS grades A to D (41 vs. 47 vs. 51 vs. 61?years, P?=?0.001) and a linear correlation between donor age and recipient age was identified (P?=?0.002). This is a reflection of the incorporation of donor and recipient matching into the national kidney allocation algorithm in the UK [14�C16]. Waiting time was longer in transplants from DDS grade B kidneys than in grades A, C, and D (547 vs. 344, 409, and 345?days, respectively, P?=?0.020). There was no difference in cold ischemia time between optimal (Grades A and B) and marginal kidneys (Grades C and D), but marginal kidneys in DDS grade D had longer cold ischemia times (CIT) than marginal kidneys in DDS grade C (1221?m vs. 979?m, P?=?0.034). The incidence of PNF was similar in all groups (4%, 2%, 0%, and 12%, P?=?0.687).