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The cutoff point for the observations of children was 3.45 points. For all patients, the measurement error was 1.2 (SD 8.0) points. The LOA ranged from ?14.5 to 16.8 (93.6% of the observations within the range). For all adult patients, the same measurement error was found. The LOA ranged from ?14.4 to 16.9 (93.2% of the observations within the range). For observations in children, the measurement error was 0.7 points (SD 7.1), with a limit of agreement ranging from ?13.1 to 14.5 subsequently (92.9% of the observations within the range). For the EASI, the overall mean difference was 6.6 points (SD 5.9) when IGA improved with one point. The MCID varied from 1.0 (anchor from 1 to 0) to 8.6 (anchor from 5 to 4). This range might be due to the small number of observations in both categories. The ROC cutoff point was 2.75 points with http://www.selleckchem.com/products/bms-911543.html 73.8% sensitivity and 57.4% specificity. Measurement error subtracted from that of the Bland and Altman analysis was 3.03 points (SD 5.8). Limits of agreement ranged from ?8.7 to 14.4 points (97.3% of the observations within the range). The overall mean difference of the POEM was 3.4 points (SD 4.8). An improvement of 1.5 points on the POEM was the ROC cutoff point (sensitivity 62.1%, specificity 66.1%). The mean measurement error was 0.8 points (SD 5.3). Therefore, LOA ranged from ?9.6 to 11.2 points (91.8% of the observations within the range). In this study, we assessed the responsiveness and the MCID of four outcome measures for AE. The results indicate that these measures are all fairly responsive but that their http://www.selleckchem.com/products/loxo-101.html ability to discriminate between patients who improved and who did not varies. The responsiveness, or sensitivity to change, of the objective SCORAD and SCORAD was fair, meaning that the area under their ROC curve was larger than 0.70. Although the EASI and the POEM http://www.selleck.cn/products/ON-01910.html had an AUC below 0.70, the differences in responsiveness were not significant as the CIs overlapped almost entirely. To calculate the MCID, we used two different analytic methods. For the SCORAD, we found a mean difference in SCORAD scores between two subsequent categories of IGA (i.e., one-point improvement on the IGA) of 8.7 points. As the SCORAD ranges from 0 to 103, and the IGA ranges from 0 to 5, this means a change of about 20% on the IGA only translates to a change of