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The open questions at the start of our study were: how sensory function develops over time in FD patients with and without ERT, with and without impaired renal function, and in direct comparison between males and females. We further asked how SF morphology would be affected by FD in direct comparison between men and women, whether renal function was an important covariate, and how SF morphology would change over time with and without ERT. We present the http://www.selleck.cn/products/lee011.html largest cohort of Fabry patients so far investigated with standardized methods for SF function and morphology to answer these questions. Between 2005 and 2010, 120 Fabry patients (median age 42, range 17�C73 years) were prospectively recruited through the W��rzburg Fabry Center for Interdisciplinary Therapy (FAZIT), a tertiary referral center. The majority of patients were subsequently treated and followed in medical centers near their homes. The cohort included 50 men (median age 40, 19�C71 years) and 70 women (median age 45, 17�C73 years). Thirty-two patients were on ERT (18 men, 14 women), biweekly infusions of agalsidase beta [1 mg/kg] in 30 and of agalsidase alpha [0.2 mg/kg] in two patients. Patients were included if FD was confirmed by ��-GAL assay and genetically ascertained. Thirty-nine patients were seen at 1-year follow-up (29 on ERT), 16 (15 on ERT) of these plus eleven patients examined at baseline but not after 1 year were seen at 2-year follow-up, 11 (10 on ERT) of the patients seen http://www.selleckchem.com/products/epacadostat-incb024360.html at 2-year follow-up were also seen at 3-year follow-up plus 8 patients from baseline, and 10 (all on ERT) of the patients seen at 3-year http://www.selleckchem.com/products/i-bet-762.html follow-up plus 3 further patients were seen at 4-year follow-up (Fig. S1). The study was approved by the W��rzburg Medical School Ethics Committee. Written informed consent was obtained from all participants. The German version of the Neuropathic Pain Symptom Inventory (NPSI) (Bouhassira et al., 2004; Sommer et al., 2011), the Graded Chronic Pain Scale (GCPS, modified for ��the last 4 weeks��) (Von Korff et al., 1992), and the Center for Epidemiologic Studies Depression Scale (CES-D) (Radloff, 1977) were used to assess pain and depression symptoms (Supporting Information). All patients underwent detailed biochemical and hematological blood tests (Supporting Information). Renal function was considered normal if glomerular filtration rate (GFR) >60 ml/min/1.73 m2 and reduced if GFR