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05). However, LLLT showed better effects than TD and ID regarding PGE2 levels and walking track analysis (P? http://www.selleck.cn/products/sch772984.html sports injuries and excessive stretching of muscle causes more than 90% of injuries [1]. Exercises involving eccentric contractions such as resistance exercises, jumping, plyometric and running with intermittent fast change of direction exercises are commonly responsible for this kind of injury [2]. Different kinds of pharmacological and nonpharmacological therapies have been used to prevent or at least mitigate the deleterious effects of this kind of injury. Among these therapies, we can highlight anti-inflammatory drugs, cryotherapy, massotherapy and electrotherapy. Diclofenac is widely used in treatment of muscle injuries and this drug belongs to the category of nonsteroidal anti-inflammatory drugs (NSAIDs), and their mechanisms of action are not fully known. It is well-known that the main role of this drug is to reduce the activity of cyclooxygenase isoforms (COX-1 and COX-2), and consequently inhibits prostaglandin synthesis [3]. However, it is important to highlight that when used orally, diclofenac may induce important adverse effects such as gastrointestinal bleeding, stomach ulcers, kidney and heart complications, http://www.selleckchem.com/products/obeticholic-acid.html among others [3, 4]. However, in topical formulations these side effects seem to be decreased [3, 5-7]. An important meta-analysis published in the British Medical Journal [8] analyzed more than 13?000 patients with chronic inflammatory diseases taking NSAIDs, including coxibs. In this study, authors demonstrated that the effect of anti-inflammatory drugs were slightly superior to placebo and due to that, there is no evidence to support the use of such drugs in these diseases, especially taken into account the important and several side effects related to long-term use. This article has aroused considerable controversy in the scientific community concerning new therapies that could be used to treat chronic inflammatory diseases. In 2007, Bjordal http://www.selleckchem.com/products/Adriamycin.html et?al. [9] have demonstrated in another meta-analysis of randomized, double-blinded, placebo-controlled trials that only topical application of diclofenac had a minimum clinically relevant efficacy in relieving pain in osteoarthritis of the knee. In recent years, several randomized, placebo-control trials were performed, confirming that low-level laser therapy (LLLT) currently represents a consistent alternative therapy to treat different diseases [10-12]. Particularly in the last 10?years, our research group has characterized the effects of the therapy in inflammatory paw edema [13], osteoarthritis [14], tendinitis [15] and skeletal muscle fatigue [16-18]. Recent studies in humans confirmed the fact that had already been hypothesized over the years. According to Samoilova et?al.