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A major cytogenetic response (MCyR) was defined as the sum of CCyR and partial cytogenetic response (i.e. 0�C35% Ph+ cells in marrow). Major molecular response (MMR) was defined as ��0��1%IS of BCR-ABL1 fusion gene transcripts, and molecular response 4��5 (MR4��5) was defined as 0��0032%IS BCR-ABL1 transcript level, equivalent to a 4��5 log reduction of BCR-ABL1 transcript level. Time to treatment failure (TTF) http://www.selleckchem.com/products/Fludarabine(Fludara).html was defined as the interval between the initiation of 2GTKI therapy and the occurrence of events that indicated failed 2GTKI therapy, including primary haematological resistance, cytogenetic resistance, loss of CCyR, development of ABL1 tyrosine kinase domain mutation, clonal evolution and progression to accelerated phase (AP) or blastic crisis (BC). Death was considered as censored for TTF. PFS was defined as the interval between the initiation https://en.wikipedia.org/wiki/Chlormezanone of 2GTKI therapy and confirmation of progression to AP or BC or death from any cause, while overall survival (OS) was calculated from the initiation of 2GTKI therapy until the date of death from any cause or of latest follow-up. The medical records were reviewed until April 2012. The demographic and disease characteristics were compared using Chi-square, Fisher's exact or Mann-Whitney's U-tests as appropriate. The treatment outcomes, such as CCyR, MMR, MR4��5, TF, PFS and OS were estimated using Kaplan-Meier method and were compared using Wilcoxon test. The cumulative incidences of CCyR, MMR, MR4��5, TF, PFS and OS were compared and plotted according to the BCR-ABL1 transcript level at 3 or 6?months, divided into http://www.selleckchem.com/products/Nolvadex.html of BCR-ABL1 transcript level were compared at each time point and every 3?months up to 4?years among the three groups using Kruskal-Wallis. Results were plotted with median values. Multivariate analysis was performed using the following variables for CCyR, MMR, MR4��5 and TF: i) previous episode of failure to achieve CCyR with Imatinib therapy, ii) resistant to Imatinib therapy (vs. intolerance), iii) 3rd line therapy (vs. 2nd line), iv) BCR-ABL1 transcript level at 3?months ��1%IS (