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The endpoints used were OS and PFS. The Chi-squared test for independence was used to assess for correlations between categorical variables, with the Yates continuity correction applied where indicated. For numerical variables, the independent samples t-test or the Mann�CWhitney test (where normality was accepted via the D��Agostino-Pearson test) were used. Statistical analyses were performed using R: A Language and Environment for Statistical Computing (http://www.R-project.org, Vienna, Austria) and medcalc for Windows, version 10.3.2.0 (MedCalc Software, Mariakerke, Belgium). P values http://www.selleck.cn/products/nlg919.html and sixty-two patients with an initial diagnosis of de novo DLBCL were drawn from multiple institutions in the United States, Canada and Europe. This cohort represents all patients treated with R-CHOP with curative intent at those institutions during the study period, for whom paraffin blocks were available. The median age of the patients was 59��5?years (range, 20�C85?years; 49% >60?years old); patients were initially diagnosed between 2000 and 2006, with the majority diagnosed in 2001 and 2002. Patients were followed for a median of 45?months (range, 1�C94?months) from the initial diagnosis of de novo DLBCL; 25% died and 37% suffered disease progression during the follow-up interval. About 2/3 of patients had low IPI scores (0�C2) and 1/3 had high IPI scores (3�C5). The distribution of IPI risk factors in this cohort is similar to that of previously reported retrospective and prospective DLBCL studies, including the original publication of the IPI model (Shipp http://www.selleckchem.com/products/bmn-673.html et?al, 1993). At the end of the follow-up interval 16% of patients with low IPI scores had died and 27% had suffered disease progression; among patients with high IPI scores, 41% had died and 54% had suffered disease progression. Table?II presents the baseline clinical characteristics in the patient population overall and with respect to each of the immunohistochemical parameters studied. There was no statistically significant http://www.selleckchem.com/products/pexidartinib-plx3397.html (P?