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The Kruskal�CWallis test was used to assess the http://www.selleckchem.com/products/byl719.html differences in the number of cohabitants among patients with different types of primary caregivers. The time-courses of each group's HDS-R, ASSD and N-ADL scores were analyzed using the Friedman test. The Wilcoxon test was used to evaluate the differences among the three groups in the change between the participants' initial HDS-R, ASSD and N-ADL scores, and those at the end of terms of 12, 36 and 60 months, whereas the Kruskal�CWallis test was used to evaluate the differences in the annual changes in the participants' HDS-R, ASSD and N-ADL scores among the three groups. The Steel�CDwass test was used to assess the differences in the annual changes in these scores in comparisons between two groups. Binomial logistic regression with a stepwise method was used to analyze the associations between various patient characteristics and the 1-year and 5-year groups. In these analyses, we analyzed the effects of age, sex, diagnosis, comorbidity, primary caregiver and the number of cohabitants, as well as the initial HDS-R, ASSD and N-ADL scores as measures of cognitive, behavioral http://www.selleck.cn/products/gsk-j4-hcl.html and functional status in model 1. In model 2, we used characteristics including age at the final attendance, sex, diagnosis, comorbidity, complication, primary caregiver and the number of cohabitants, and the final HDS-R, ASSD and N-ADL scores, respectively. Caregivers were divided into five categories (spouse, son, daughter, daughter-in-law and others). ��Others�� included other relatives and caregiving staff. The Hosmer�CLemeshow test was used to assess the goodness-of-fit of these models. There were a few pieces of missing data; however, there were no significant differences in any variable between the whole sample and the sample used in the binomial logistic regression analysis. All statistical analyses were carried out using spss version 17.0 (SPSS, Chicago, IL, USA) and Statcel3 (OMS Shuppan, Tokorozawa Saitama, Japan).[8] P-values of http://www.selleckchem.com/products/BEZ235.html HDS-R, ASSD, N-ADL, the final N-ADL scores, and the primary caregiver distributions of the 1-year and 5-year groups were significantly different, and many of the patients in the 5-year group were cared for by their daughters-in-law. The initial HDS-R and N-ADL scores of the 1-year group were significantly lower than those of the 5-year group. In contrast, the initial ASSD score of the 1-year group was significantly higher than that of the 5-year group; and also, the final N-ADL score in the 5-year group was significantly lower than that of the 1-year group. There were no significant differences in age, sex, diagnosis, comorbidity, complication or the number of cohabitants among the three groups (Table?1).