HA is a macromolecular glucosamine

Hyaluronic acid (HA) is a macromolecular glucosamine with a molecular weight of 40-80 million, which is mainly synthesized by mesenchymal cells. HA mainly exists in connective tissue, skin, joint fluid, cartilage and vitreous humor. The tissue matrix that constitutes the site. Serum HA is a good indicator that reflects the function of liver endothelial cells, reflects active fibrosis, and predicts liver cirrhosis.

The level of serum HA mainly reflects the function and degree of damage to liver endothelial cells. (1) Liver cirrhosis: Long course of disease, severe fibrosis and degeneration of liver tissue, and serum HA level significantly increased, even reaching more than 1000μg/L, mainly because of portal-caval shunt during liver cirrhosis, and the systemic blood carrying HA enters the liver for catabolism. Decrease; liver tissue is damaged, the number of liver endothelial cells is reduced, and the metabolic function is reduced. The increased level of HA in liver cirrhosis is closely related to the degree of liver pathological changes. HA level of 250μg/L can be judged as liver cirrhosis.　(2) Chronic active hepatitis and chronic persistent hepatitis: The level of serum HA has also changed significantly, the former is higher than the latter, and its level is also related to the degree of liver cell damage and liver fibrosis activity. The level of HA reaches 165μg/L, which can be used as a boundary between chronic active hepatitis and chronic persistent hepatitis.　(3) Acute hepatitis: Due to the damage of liver cells, necrotic substances indirectly stimulate the synthesis of HA in interstitial cells of the liver, and the level of serum HA may increase slightly.　For patients with liver disease, the overall level of HA according to the degree of damage and pathological changes is as follows: liver cirrhosis>chronic active hepatitis>chronic persistent hepatitis>acute hepatitis. It can be seen that HA is better than ALT as an indicator of liver cell fibrosis damage. Because ALT stops destroying liver cells and fibrosis in the liver, it does not increase during liver cirrhosis.　(4) Liver cancer: HA can also increase significantly. (5) Lung cancer: Due to the increased release of HA and hyaluronidase inhibitors from cancer infiltrating tissues and surrounding connective tissues, especially in lung mesothelial cell carcinoma, the serum HA level can be significantly increased, and the alveolar lavage fluid HA (ie BAL- The increase of HA) level far exceeds the level of serum HA (S-HA). If the ratio of BAL-HA/S-HA increases significantly, it has certain reference value for the diagnosis of lung malignant tumors.　(6) Chronic nephritis and chronic renal insufficiency: The level of serum HA was significantly higher than that of the normal control group, and it was positively correlated with creatinine and urea nitrogen. Serum HA in nephropathy can reflect the degree of renal damage. This is related to the accumulation of toxic metabolites in the blood to stimulate the synthesis of HA by interstitial cells. However, HA levels did not change significantly before and after renal dialysis. Since HA is a macromolecular substance, and the dialysis membrane can only filter substances with a molecular weight of less than 35,000, the dialysis method cannot remove HA. As an indicator of renal damage, HA has a certain reference value to reflect the degree of renal damage.

Precautions

When the liver and kidney functions are impaired, the ability to decompose hyaluronic acid is reduced, and the hyaluronic acid in the serum is increased, which is proportional to the degree of disease.

About Us

Creative BioMart has many years of research experience in life science and biological technology, and owns a mature team of experts for biology. Creative BioMart utilizes its expertise in the field of biology to provide customers with biomarker-related services and products. Here are some: Glycated albumin assay, Glycated hemoglobin ELISA test, glycoprotein 130 test, Haptoglobin ELISA test, etc.