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Means, medians and ranges were reported https://en.wikipedia.org/wiki/Crotamiton for continuously coded variables. Furthermore, the ROC coordinates were used to define and plot the probability of correctly staging pN1 patients according to LN count, as in previously described methodology.4,10,11 Patients were further stratified into three groups according to D'Amico tumor risk categories:12 (i) low risk tumors: patients with clinical stage T1c, T2a and PSA level ��10?ng/mL and Gleason score ��6; (ii) high risk tumors: patients with clinical stage T2c or a PSA level >20?ng/mL or a Gleason score ��8; and (iii) intermediate risk tumors: the remaining patients with clinical stage T2b or a PSA level between 10 and 20?ng/mL or a Gleason score of 7. The aforementioned analyses were repeated http://www.selleckchem.com/products/rxdx-106-cep-40783.html within each risk category to examine outcome variability according to tumor characteristics. Finally, univariable and multivariable logistic regression models assessed the relationship between LN count and the probability of pN1 stage. Covariates consisted of patient age at surgery, race (white vs black vs others), clinical stage (T1c vs T2a/b vs T2c), primary Gleason grade (��3 vs 4 vs 5), secondary Gleason grade (��3 vs 4 vs 5), serum PSA (0.1�C4.0 vs 4.1�C10.0 vs >10), year of surgery (2004 vs 2005 vs 2006) and SEER registry. All statistical tests were carried out with the R statistical package system (R Foundation for Statistical Computing, Vienna, Austria) or spss, version 15.0 (SPSS, Chicago, IL, USA). Between 2004 and 2006, 20?789 patients were treated with RP and PLND within the SEER database (Table?1). The average http://www.selleckchem.com/products/CP-673451.html age was 60.9?years (median 61.0, range 34.0�C90.0). The majority of patients were white (84.5%) and resided in the California SEER registry (24.0%). Overall, 64.8% had a PSA level between 4.1 and 10.0?ng/mL, 62.3% were T1c/2a, 77.2% had a primary Gleason grade of 3 or less, and 49.9% had a secondary Gleason score of 3 or less. The mean number of LN count was 6.4 nodes (median 5.0, range 1.0�C40.0). Tumor was classified as low, intermediate and high risk in 21.6, 53.0 and 25.4% of patients, respectively. Overall, the rate of pN1 stage was 2.5% (Table?1). The rate of PSA >10?ng/mL was 45.4% in pN1 versus 17.7% in pN0 (P?