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More men smoked and consumed alcohol than women (P? http://www.selleckchem.com/products/BI6727-Volasertib.html was lower in older than in younger men (P for trend,? http://www.selleckchem.com/products/cb-839.html and women (P for trend, http://www.selleck.cn/products/wnt-c59-c59.html assessments) and 1868 women (7095 assessments). Changes in SMI by birth cohort were estimated using the general linear mixed-effect model controlled for smoking, alcohol consumption, years of education, annual income and comorbidities (hypertension, heart disease, dyslipidemia, diabetes mellitus and stroke). The main effects of time (P?=?0.03), birth cohort (P?