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Surveillance for HBV recurrence was performed per local protocol but measuring HBsAg and anti-HBs titers every month for 1 year, then every 3 months thereafter; HBV DNA levels were obtained at 1, 3, 6 and 12 months post-LT and then every 6�C12 months thereafter, or more frequently if suspicion of treatment failure (i.e. HBsAg positivity, ALT elevation). Posttransplant serum samples were not collected at specified time points in the HBV monoinfected control group. Descriptive statistics included http://www.selleck.cn/products/BafilomycinA1.html median, mean, quartiles and range as appropriate. The primary outcomes of interest were patient and graft survival and HBV recurrence defined by detection of serum HBsAg and HBV DNA. Secondary outcomes included post-LT CD4 cell counts, and frequency and outcome of acute http://www.selleckchem.com/products/hydroxychloroquine-sulfate.html rejection episodes. Cumulative patient and graft survival and rates of HBV recurrence were calculated using Kaplan�CMeier methods. The log-rank test was used to compare HBV-HIV coinfected and HBV monoinfected groups, with a p-value of http://www.selleckchem.com/products/blz945.html in the coinfected patients was 3.5 years and in the monoinfected patients was 4.0 years. The cumulative patient and graft survival at 1 and 3 years in the HBV-HIV coinfected patients was 85% compared with 100% in the HBV monoinfected group (p = 0.08, log-rank test) (Figure 1). Patient and graft survival results were unchanged by exclusion of the 2 patients with HCV coinfection. The three deaths in the HBV-HIV coinfected group all occurred in the first year post transplantation and were unrelated to HBV recurrence or AIDS-defining opportunistic complications.
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