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However, elevated HR (>90?bpm) was not significantly associated with an increased CAV development, so the authors stated that higher HR was not a risk factor for coronary atherosclerosis. Surprisingly, a significant association was achieved between HR https://www.selleckchem.com/products/Adriamycin.html higher in the group with HR https://www.selleckchem.com/products/obeticholic-acid.html with a HR >90?bpm post-HTx had an increased risk of death from any cause of 2.8 times greater than patients with a HR https://www.selleck.cn/products/sch772984.html separation between both groups from the start of the observation period. This separation was more pronounced as time went by. Differences in cumulative survival between both groups were already of 13% at 500?days after HTx (100% vs. 87%), increasing to 18% at 1000?days (92% vs. 74%) and up to 23% at 2000?days after HTx (81% vs. 58%). Although no significant differences were found in baseline characteristics of both groups, a statistically significant difference (30.9% vs. 17%, P?=?0.033) was observed in the incidence of PGF in favor of the group with a HR higher than 100?bpm. This factor needs to be taken into account as PGF is per se a factor that has proven to reduce survival in HTx recipients. However, PGF has been associated with an increased early mortality in the immediate post-transplant period [23].