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Image guidance using CT on rails or B-mode Acquisition and Targeting ultrasound was used for all patients. Physical examination, toxicity assessment and complete blood count were obtained weekly during chemoradiation treatment and at week 10 (2 weeks after finishing chemoradiation). Toxicity was scored using the Common Terminology Criteria for Adverse Events, Version 3.0. In addition, on weeks 1, 4, and 7, a complete metabolic panel including liver function tests was obtained. Serum PSA level was checked every 3 months during the follow-up http://www.selleck.cn/products/ve-821.html period. Biochemical progression-free survival (PFS) was measured from the date of study enrollment to death from any cause or biochemical failure using the Phoenix definition [17]. Survival curves were estimated using the Kaplan�CMeier technique. Between December 2005 and January 2010, 18 men with high-risk or locally advanced prostate cancer were enrolled. The median (range) age was 62?(45�C77)?years (Table?1). The median (range) follow-up was 2.2?(1.0�C3.9)?years. All 18 patients completed their RT and 16 completed all planned chemotherapy doses. One of the first three patients at dose level I (10?mg/m2 docetaxel) developed grade 3 diarrhoea, which resolved after holding one dose of chemotherapy. This patient received seven of the planned eight weekly doses. In the expansion cohort of three more patients, one developed a grade 3 elevation in liver function tests, which resolved while the two doses of chemotherapy were held (completed six of eight cycles). The increase in liver function tests in this patient was not clearly related to the http://www.selleckchem.com/products/Vorinostat-saha.html study treatment and was most probably related to concomitant medication. However, to further ensure the safety of this dose level, three more patients were added and no further DLT was seen. At dose level II (15?mg/m2 docetaxel), one of the first three patients developed grade 3 diarrhoea that resolved before the next weekly dose of chemotherapy. Although this patient was able to complete all protocol chemotherapy treatment, he was assigned to have DLT and an additional three patients were treated at dose level II. No DLT was seen in the expansion cohort for dose level II. None of three patients treated at dose level III (20?mg/m2) developed DLT. Overall, diarrhoea occurred in seven patients (five grade 1, two grade http://www.selleckchem.com/products/Cisplatin.html 3; Table?2). Lymphopenia developed in 11 patients (one grade 1, five grade 2, five grade 3). Other toxicities included: grade 2 acute urinary symptoms, fatigue and hypersensitivity reactions. No patient developed grade 4 or 5 toxicity. All patients in this study achieved a post-treatment PSA of ��1?ng/mL, including 13 patients who had an undetectable PSA (