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[49] Although the three retrospective studies showed better potency rates of RARP over LRP, they failed to reach statistical significance. Asimakopoulos et?al. convincingly showed in the only prospective and randomized trial to date that RARP had a clear advantage over LRP in terms of 12 months potency rates (77% vs 32%, respectively).[49] A recent meta-analysis[80] of comparative studies described the prevalence of erectile dysfunction as 47.8% after ORP and 24.2% after RARP. The cumulative analysis showed a statistically significant advantage in favor of RARP (OR 2.84; P?=?0.002), and the absolute risk reduction for erectile dysfunction was 23.6%. The meta-analysis also reported that the prevalence of erectile dysfunction was 55.6% after LRP and 39.8% after RARP. Cumulative http://www.selleckchem.com/products/CP-673451.html analysis http://www.selleckchem.com/products/rxdx-106-cep-40783.html showed a non-statistically significant trend in favour of RARP (OR 1.89; P?=?0.21). Primum non nocere (First, do no harm) has always been the fundamental belief in the history of medicine. The epitome of oncological surgery is complete oncological clearance with no morbidities or complications. It might be impossible to achieve this ideal, and hence in our quest to secure oncological clearance, perioperative and postoperative morbidities and complications are equally important considerations in patients' choice of therapy. Patients should never suffer more from their treatment than from their disease itself. We identified 13 comparative studies (Table?4) comparing operative time of RARP with ORP.[26-28, 30, 32, 34, 36, 37, 40, 43, 83, 85, 87] The results are conflicting, with six studies[26, 30, 32, 34, 37, 43, 85] reporting longer operative time for RARP as compared with ORP, and the other seven studies showing either similar[27, 28, 36, 40] or shorter[83, 87] operative time. It is interesting to note that of the seven studies that reported a https://en.wikipedia.org/wiki/Crotamiton longer operative time for RARP, five series[26, 30, 34, 37, 43] had