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The patient details for the two surgeon's groups are listed in Table?1. The two surgeons operated on 47 and 20 patients, respectively. Operative outcomes are summarised in Table?2 and include surrogate markers for oncological outcome, e.g. positive surgical margin (PSM) rates and LN yields. All patients underwent extended PLND, except one who did not receive any PLND and five who received a limited PLND. Those six patients were the first six totally intracoproreal RARCs performed at the centre. Apart from less blood loss in surgeon B's series, there were no significant differences in operative outcomes seen between surgeon A and http://www.selleck.cn/products/ON-01910.html B when compared for other variables (Table?2). The patients were then divided into groups of 10 in each individual surgeon's consecutive series and assessed for effect of learning curve using anova. Comparing the data of the two surgeons showed progressively diminishing operation times from the first to the last groups in both surgeons' series (Figs?1, 2). The decrease in operation time seen with surgeon A was statistically significant (P http://www.selleckchem.com/products/loxo-101.html for surgeon B from a mean of 420?min for his first 10 patients to a mean of 395?min for his second 10 patients was not significant (P = 0.1; Fig.?1). For surgeon A, the risk of conversation to open surgery also decreased with a 30% conversion rate in the first group to 0% in latter groups http://www.selleckchem.com/products/abc294640.html (P