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35, 36 Without a change in the current hip fracture incidence, the total number of hip fractures, on average, would increase by similar proportions in each group. More targeted hip fracture prevention efforts are needed to minimize the potential negative effects of an increasing number of hip fractures with the aging population, particularly among Hispanics, on the nation's health. All investigators receive research http://www.selleckchem.com/products/z-vad-fmk.html support from Amgen. Additional financial disclosures include: JRC: Research grant: Eli Lilly, Merck, Novartis, Proctor & Gamble, Roche; Consulting fees: Merck, Amgen, Eli Lilly, Roche, Novartis. KGS: Research grant: Eli Lilly, Novartis, Merck; Consulting fees: Eli Lilly, Novartis, Merck, Amgen. This research was supported by a contract between UAB and Amgen, Inc. Only the authors had access to the data. The analysis, presentation and interpretation of the results were solely the responsibility of the authors. Authors' roles: Study design: NCW, JRC, ESD, and KGS. Data acquisition, JRC, ESD, MLK, MAM, and KGS. Data analysis: NCW and WKS. Data interpretation: NCW, JRC, ESD, MLK, MAM, KGS, WKS, HY, and JZ. Manuscript drafting: NCW. Manuscript revision: NCW, JRC, ESD, MLK, MAM, KGS, WKS, HY, and JZ. NCW had full access to all of the data in the study and takes responsibility for the integrity of the data and accuracy of the analyses. ""The relationship http://www.selleckchem.com/products/ly2157299.html between osteoarthritis (OA) and osteoporosis remains controversial. This study was designed to determine the association between hip and knee radiographic OA and change in total hip bone mineral density (BMD) over 2.6 years. A total of 867 population-based randomly selected subjects (mean age 62 years, range 51 to 80 years, and 49% female) were included. Hip and knee joint space narrowing (JSN, 0 to 3) and osteophytes (0 to 3) in both lower limbs was assessed using http://www.selleck.cn/products/s-gsk1349572.html Altman's atlas. Total hip BMD was measured by dual-energy X-ray absorptiometry (DXA). We found that radiographic OA (score of JSN or osteophytes > 0) was common in this sample (hip 45%, knee 68%). In multivariable analyses, percentage change in total hip BMD per year was predicted by right and left hip axial JSN (��?=?�C0.25% and �C0.29% per grade, respectively, both p?