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001 to 0.043). After adjustments for sex, age, height, and weight, serum osteocalcin levels were significantly lower in subjects with MS than those without (P http://www.selleck.cn/products/ly2157299.html levels by MS status was noted in both normal glucose tolerance (NGT) and abnormal glucose tolerance (impaired fasting glucose (IFG) or diabetes) group (P = 0.034 and P http://www.selleckchem.com/products/sch772984.html known OP who developed VCF's after spine flexion exercises http://www.selleckchem.com/products/dabrafenib-gsk2118436.html (SFE's), and recommended that SFE's not to be prescribed in patients with OP of the spine. Here, we report four previously healthy individuals with low bone mass and exercise-induced fractures. Patient #1 An 87 yo F had severe back pain while performing SFE's during strenuous yoga with instructor supervision: Spine x-rays: L2 VCF and mild anterior wedging of several thoracic vertebrae Lumbar spine (LS) OP with T Score - 4.3 Physical examination: tandem test -3, LS pain with extension, and 3/4 inch leg length discrepancy with lumbar curve. Patient #2 A 61 yo F with osteopenia had severe back pain with strenuous SFE's during yoga: Spine x-rays: T4 VCF LS BMD T Score -1.8. Patient #3 A 76 yo M with osteopenia had severe back pain while lifting 35-40 lbs using an exercise machine anterior to his chest with spine flexion at his local physical therapy facility: Spine x-rays: L1, L2, and L5 VCF's Hip T-score -1.2. Patient #4 A 73 yo M had acute back pain while jogging in preparation for a triathlon: Spine x-rays: T7 VCF LS BMD T Score -1.9. SUMMARY: OP is characterized by low bone mass, loss of bone microstructure and fracture risk. OP musculoskeletal rehabilitation is a non-pharmacologic approach to limit bone loss. Although exercise has been shown to be an effective method for improving BMD and fracture risk, our subjects developed VCF's while engaged in exercise.