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""Background:?Dual-chamber pacing is believed to have an advantage over single-chamber ventricular pacing. The aim of the study was to determine whether elderly patients with implanted pacemaker for complete atrioventricular block gain significant benefit from dual-chamber (DDD) compared with single-chamber ventricular demand (VVIR). Methods: The study was designed as a double-blind randomized two-period crossover study��each pacing mode was maintained for 3 months. Thirty patients (eight men, mean age 76.5 �� 4.3 years) with implanted PM were submitted to a standard protocol, which included an interview, functional http://www.selleck.cn/products/dabrafenib-gsk2118436.html class assessment, quality of life (QoL) questionnaires, 6-minute walk test, and transthoracic echocardiographic examinations. QoL was measured by the SF-36. All these parameters were obtained on DDD mode pacing and VVIR mode pacing. Paired data were compared. Results:?QoL was significantly different between the two groups and showed the best values in DDD. Overall, no patient preferred VVIR mode, 18 preferred DDD mode, and 12 expressed no preference. No differences in mean walking distances were observed between patients with single-chamber and dual-chamber pacing. VVI pacing elicited marked decrease in left ventricle ejection fraction and significant enlargement of the left atrium. DDD pacing resulted in significant increase of the peak systolic velocities in lateral mitral annulus and septal http://www.selleckchem.com/products/DAPT-GSI-IX.html mitral annulus. Early diastolic velocities on both sides of mitral annulus did not change. Conclusion:?In active elderly patients with complete heart block, DDD pacing is associated with improved quality of life and systolic ventricular function compared with VVI pacing. (PACE 2010; 583�C589) ""Aims:SafeR performance versus DDD/automatic mode conversion http://www.selleckchem.com/products/Adriamycin.html (DDD/AMC) and DDD with a 250-ms atrioventricular (AV) delay (DDD/LD) modes was assessed toward ventricular pacing (Vp) reduction. Methods:?After a 1-month run-in phase, recipients of dual-chamber pacemakers without persistent AV block and persistent atrial fibrillation (AF) were randomly assigned to SafeR, DDD/AMC, or DDD/LD in a 1:1:1 design. The main endpoint was the percentage of Vp (%Vp) at 2 months and 1 year after randomization, ascertained from device memories. Secondary endpoints include %Vp at 1 year according to pacing indication and 1-year AF incidence based on automatic mode switch device stored episodes. Results:?Among 422 randomized patients (73.2 �� 10.6 years, 50% men, sinus node dysfunction 47.4%, paroxysmal AV block 30.3%, bradycardia-tachycardia syndrome 21.8%), 141 were assigned to SafeR versus 146 to DDD/AMC and 135 to DDD/LD modes. Mean %Vp at 2 months was 3.4 �� 12.6% in SafeR versus 33.6 �� 34.7% and 14.0 �� 26.0% in DDD/AMC and DDD/LD modes, respectively (P