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In Cox proportional hazards models, we defined pulmonary event time as years from allo-HSCT to the time of event for each patient. Pulmonary event time was defined as 0 if the patient experienced the event pre�Callo-HSCT. The time was censored http://www.selleckchem.com/products/byl719.html at the last follow-up for those patients who had not experienced the abnormalities. Cumulative incidences for the event of interest were obtained using the SAS Macro CIN (Cary, NC) based on Gray's approach accounting for competitive risks. Table 1 summarizes the characteristics of the patients. The median age at allo-HSCT was 12.7 years (range, 6.6-21.3 years) and the median duration of follow-up after HSCT was 8.9 http://www.selleck.cn/products/ipi-145-ink1197.html years (range, 1.7-16.4 years). The median number of evaluable PFTs per patient was 8 (range, 2-21). Although various conditioning regimens were administered, the vast majority of patients received cyclophosphamide and total body irradiation. Cytarabine was used before 2002 and was replaced by thiotepa thereafter. Acute GVHD was observed in 49.4% and extensive chronic GVHD was limited to only 6.7% of the patients. While 15.7% of the patients developed pulmonary events within 1 year post�Callo-HSCT, 7.9% experienced chronic respiratory problems (ie, wheezing and cough) more than 1 year post�Callo-HSCT. The respiratory problems within 1 year post�Callo-HSCT include 11 cases of pneumonia, 2 of bronchiolitis obliterans organizing pneumonia, and 1 of pleural effusion with pneumothorax. Abnormal lung parameters (ie, obstruction, air trapping, restriction, or reduced diffusion capacity) were pre-existing in 12.4% to 40.4% of patients pre�Callo-HSCT (Table 2), and respiratory dysfunction developed in 15.7% to 64% post�Callo-HSCT. Patients with abnormal pre�Callo-HSCT values of http://www.selleckchem.com/products/SB-431542.html FEV1/FVC (P = .0083), FEV1 (P = .011), RV (P