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All the analyses were retrospective. Corrected risk estimates and identification of independent predictors of MACE were performed using a Cox proportional hazard regression model, including as covariates variables found to differ significantly in univariate analysis between patients with and without events. In order to minimize the effect of potential selection bias for implantation of DES, we used a propensity score-based correction by including the propensity variable in the regression model. The propensity model calibration was assessed by the Hosmer-Lemeshow http://www.selleckchem.com/products/pirfenidone.html goodness-of-fit test and receiver operating characteristic curve analysis (c-statistic). Two-tailed tests of significance are reported. For all comparisons, a p value of http://www.selleck.cn/products/Paclitaxel(Taxol).html (SPSS Inc., Chicago, Ill, USA). During the study period, a total of 95 patients underwent unprotected LMCA PCI. Baseline patient characteristics are summarized in Table 1. Briefly, mean age was 63��12 years (18.9% older than 75) and most were male (81%); there was a high prevalence of traditional cardiovascular risk factors and clinically overt cardiovascular disease, 29.5% with a previous history of MI and 39% with a previous revascularization procedure. Forty patients (42.1%) were treated in the setting of an acute coronary syndrome, 12 of them with ST-elevation MI. Overall, four patients had cardiogenic shock at presentation. Compared to patients that were free from MACE at five years|, patients in whom the primary endpoint occurred were older and had a higher prevalence of hypertension, peripheral arterial disease and previous MI. At presentation, patients with any MACE at five years were more likely to be enrolled http://www.selleckchem.com/products/Maraviroc.html in the context of an acute coronary syndrome, MI and cardiogenic shock. Angiographic and procedural characteristics are shown in Table 2. Only a small proportion of patients had isolated LM disease (14.7%) and mean SYNTAX score was 24.2��11.8. The anatomic features of LM disease are described in detail in Figure 1; 55.8% were distal LM lesions, most with ostial/proximal left anterior descending coronary artery involvement (Medina classification 1-1-0). Overall, a single-stent strategy was employed in 68.5% of the procedures and in approximately one-third of cases only the LM was treated. The implantation of a DES was the most frequent choice (81.1%), mostly using the Taxus? stent (50.6% of overall DES). In nearly half of the patients (40.6%), glycoprotein IIb/IIIa inhibitors were administered during the procedure. PCI was guided by intravascular ultrasound in six cases (6.3% of the overall cohort), five of them in the group without MACE, although the difference was not statistically significant.