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63, P > 0.05; time factor: F4,100= 65.14, P 0.05). Similar effects were observed for the groups treated with 5-azaC or vehicle (treatment factor: F3,76= 1.63, P > 0.05; time: factor F4,76= 48.33, P 0.05). None of the treatments induced any significant difference in the total distance moved in the OFT (5-azaD: F4,25= 0.54, P > 0.05; 5-azaC: F3,20= 0.57, P > 0.05; Figure?2). 5-azaD reduced immobility time when injected immediately or 5?h after pretest (F3,24= 17.25, P http://www.selleckchem.com/products/pifithrin-alpha.html not when administered 1?h before the test (Dunnett's test, P > 0.05, Figure?5). As in experiment one, systemic treatment with 5-azaD, at the dose of 0.4?mg��kg?1 significantly reduced immobility time (mean �� epm of saline and 5-azaD respectively: 135 �� 20 and 47.8 �� 31, t10= 2.434, P http://www.selleckchem.com/screening/pfizer-licensed-library.html http://en.wikipedia.org/wiki/Temsirolimus (F3,28= 3.59, P