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Candidates for HU therapy were ?25 years old (9.7 SD), with 87% (n = 688) blacks and 57% (n = 439) women. In addition, 86% (n = 662) had ED visits, while 64% (n = 495) received red blood cell transfusions, 39% (n = 302) received long-acting opioids, and 7% (n = 52) received deferoxamine. Prevalence of HU use was http://www.selleckchem.com/products/forskolin.html low; only 38% (n = 292) of patients had at least one prescription claim for HU. Hence, 62% (n = 477) of patients did not have any prescription for HU, indicating potential under use of this therapy. SCD patients were stratified as HU users and non-HU users. Overall, sufficient evidence existed that race (��2 = 4.5, P = 0.034), red blood cell transfusions (��2 = 16.3, P http://www.selleckchem.com/products/cx-5461.html 83% (n = 322) received one or more HU prescriptions with 28�C30 days http://www.selleck.cn/products/AZD0530.html supply however, the number of prescriptions dispensed varied. Of these patients, 70% (n = 227) received at least three HU prescriptions during the study period; conversely, at least 30% (n = 95) discontinued HU therapy after two prescriptions. Of the 384 HU users, 63% (n = 241) received two or more HU prescriptions with a at least 28 days and dispensing lapses less than 90 days. Of these patients, 70% (n = 168) took less than 60% of their cumulative daily dose and had frequent lapses in their prescription refills. Conversely, ?15% (n = 37) had a high MPR (MPR �� 80%), while an additional 15% (n = 36) had a MPR between 60 and 79%. See Figure 1 (Supporting Information). Adjusted odds ratios summarized in Table II indicated that SCD patients who received red blood cell transfusions (OR = 1.62, 95% CI = [1.15, 2.27]), iron chelation (OR = 2.25, 95% CI = [1.23, 4.12]), long-acting opioids (OR = 2.43, 95% CI = [1.96, 3.03]) had higher odds of using HU. Patient demographics (race, age, and gender), and use of emergency department medical resources did not have a significant effect on the odds of HU use. Our retrospective study of Florida Medicaid recipients found a low prevalence of HU use, which was consistent with previous studies by Lanzkron et al. [7, 8]. In the examination of the Maryland Medicaid data only 38% of patients who averaged 3 or more hospitalizations for every 12 month enrollment period had a HU refill claim [8]. A recent publication by Candrilli et al.