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1�C3 The two plexuses appear to be interconnected as some descending interneurons within the myenteric plexus project to the submucous plexus.4,5 Myenteric and submucous Dogiel Type-II sensory neurons, which have nerve terminals that extend down to the mucosa, also have projections to both plexuses in the small and large intestine.4,5 The myenteric plexus in the large bowel generates a rhythmic, neurally mediated propagating contraction called the colonic migrating motor complex (CMMC),6�C10 which is necessary for the propulsion of fecal pellets in the mouse.10 The CMMC is a complex motor pattern that occurs spontaneously, or can be evoked by circumferential stretch or by mechanically stimulating the mucosa.10 Mucosally evoked CMMCs are substantially reduced or blocked by ondansetron applied to the site of stimulation http://www.selleckchem.com/products/Temsirolimus.html suggesting that the stimulus releases 5-HT from mechanosensitive enterochromaffin cells (ECCs) in the mucosa that activates 5-HT3 receptors on the mucosal endings of myenteric Dogiel Type-II (AH) neurons, which underlie the initiation, generation, and propagation of the CMMC.8�C10 Mechanical stimulation of the mucosa or luminal distension releases 5-HT from ECC to also activate Dogiel Type-II (AH) neurons in the submucous plexus, which project to the myenteric plexus, by stimulating 5-HT1P/4 receptors on their endings.2,3,11�C13 Furthermore, mucosal stimulation leads to the reflex activation http://en.wikipedia.org/wiki/I%CE%BAB%CE%B1 of submucous secretomotor neurons that cause an increase in short circuit current, indicative of Cl- secretion across the epithelium.2,3,13 Early studies have suggested a connection between motility and secretion in the small intestine and colon (see2,3). More recently, intracellular recording from single submucous neurons or by measuring the dilation of arterioles in response to intraluminal distention or mucosal stimulation was shown to activate secretomotor reflexes in the guinea-pig small intestine; apparently through long (>15?mm) descending http://www.selleckchem.com/products/DMXAA(ASA404).html interneural nerve pathways within the myenteric plexus,14,15 rather than through the short (