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[24-26] Fat measurements were all carried out by one radiologist (KIR), who was blinded to patient information, clinical treatment and outcome. Given the absence of normative data on VFA in the literature, values in our patient collective were dichotomized using the median of observed distribution as the cut-off.[26] The follow-up period was defined as the time from the date of surgery to the date of the last follow-up examination or death. A distinction was made between tumor-related and non-tumor-related causes of death. Information regarding the exact date and cause of death was obtained in all cases from the primary http://www.selleckchem.com/products/CP-673451.html care physician or a close family member or from the available hospital records if the patient was regularly followed up at one of the participating institutions. The primary end-point of the study was tumor-specific survival. Continuous variables were reported as means and SD for parametric distributions or as medians and IQR for non-parametric distributions. The ��2-test and Fisher's exact test were carried out to assess differences in covariate distributions between BMI and BSA categories. The t-test was applied to compare mean values between two populations in case of metric values and normal distribution. Kaplan�CMeier survival times were calculated, and subgroups were compared using the log�Crank test statistic. https://en.wikipedia.org/wiki/Crotamiton Multivariate Cox regression models were used to assess the association between survival and BMI BSA adjusted for different clinical and patient covariates. Covariates were those factors proven to be significantly associated with BMI/BSA level as well as approved and accepted general prognostic factors in RCC. spss 19.0 (IBM SPSS Statistics, Armonk, NY, USA) was used for statistical assessment. P-values below 0.05 were considered significant in all tests. All P-values were two-sided. All patients included (n?=?2030) had a median (mean) follow up of 57 months (66 months; IQR 30�C96); during this period, 539 (26.7%) died of RCC, and 177 (8.8%) died of other causes. The mean (median) BMI of all patients was 27.1?kg/m2 (26.5; SD?��?4.5). A total of 681 patients were classified as normal-weight, 885 as preobese and 445 as obese according to WHO criteria. Because of the small number of underweight http://www.selleckchem.com/products/rxdx-106-cep-40783.html patients (n?=?19), they were grouped together with normal-weight patients for further analysis. The mean and median BSA value of the total population was 1.93?m2 (SD?��?0.21); the mean BSA of 2.01?m2 (SD?��?0.19) for male and 1.80?m2 (SD?��?0.19) for female patients was slightly above the European average of 1.98?m2 for men and 1.74?m2 for women. Patients with a higher-than-average BSA were significantly younger than those with a lower-than-average BSA (mean age, 61.0 vs 63.9 years; P?