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$4,387 among the insured. Conclusions: The implementation of a standardized VTE care pathway resulted in more cost-effective care for patients admitted to our hospital and minimized the previously observed differences in care by insurance status. Full 1-year results postcare pathway implementation will be presented. Background: There is currently no consensus on whether standard dosing of UFH for VTE (80 U/kg bolus, 18 U/kg/hr infusion) apply to patients who are considered http://www.selleck.cn/products/Erlotinib-Hydrochloride.html obese. Existing literature suggests that these doses may result in initial over-anticoagulation in obese patients. The purpose of this study is to evaluate the performance of the VTE heparin protocol in achieving therapeutic anticoagulation in patients http://www.selleckchem.com/products/ABT-263.html who are considered obese. Methods: From February 2011 to August 2011 (6 months), 78 patients on the VTE heparin protocol were identified. Patients were separated into normal weight or obese by on total body weight, or BMI, for further analysis. The primary outcome was the time to stable therapeutic anticoagulation. Secondary outcomes included the average initial aPTT, the time to first therapeutic aPTT, and the average maintenance dose required to achieve stable therapeutic anticoagulation. Results: The primary endpoint in the overall cohort was 49 �� 33 hr. Results for secondary outcomes include an initial aPTT of 122 �� 78 sec (goal aPTT for UCH is 68�C90 sec), http://www.selleckchem.com/products/MK-2206.html a time of 24.1 �� 15.7 hr for the first therapeutic aPTT, and a maintenance dose of 15.2 �� 4.1 U/kg/hr to achieve stable therapeutic anticoagulation. Patients weighing > 100 kg had a higher initial aPTT (mean 146 �� 83.1 sec) and lower average maintenance dose (mean 13.7 U/kg/hr, ��4.4) than those who weighed
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