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4%) compared to placebo with no significant increase in major bleeding. Semuloparin awaits FDA approval for the indication of preventing VTE in cancer patients receiving chemotherapy and is not currently available. Two other RCTs focused on pancreatic cancer, generally considered a very high-risk site for VTE. In the CONKO-004 study (reported only in abstract form thus far), http://www.selleckchem.com/products/i-bet-762.html VTE occurred in 5.0% (8 of 160) of patients randomized to enoxaparin (1 mg kg?1 daily for 3 months, then 40 mg daily) versus 14.5% (22 of 152) in the observation arm (P http://www.selleckchem.com/products/epacadostat-incb024360.html throughout the whole follow-up period was also reduced from 28 to 12% (P = 0.039), a 58% risk reduction. Lethal VTE (at http://www.selleck.cn/products/lee011.html that LMWH, warfarin and aspirin are likely to be similarly effective prophylactic regimens, except in elderly patients where warfarin showed less efficacy than LMWH. Aspirin and other antiplatelet agents such as clopidogrel could potentially have antithrombotic effects in cancer populations and would be highly cost-effective; however, much more data are necessary than currently available. Together, these studies demonstrate that outpatient thromboprophylaxis is feasible, safe and effective. However, the low event rate seen in PROTECHT and SAVE-ONCO emphasizes the importance of patient selection and argues against a broad application of prophylaxis for cancer patients. Indeed, when the risk score was applied to the SAVE-ONCO population, rates in the placebo arm were higher and risk reduction was therefore greater (5.4% in the placebo arm vs. 1.4% in the semuloparin arm, for score �� 3 [HR 0.