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Echocardiographically determined LVEF, filtered QRS (SAECG), NSVT episodes > 1/24 hours, VPBs > 240/24 hours, DC, mean Heart Rate, SDNN/HRV, mean QTc (24 hour HOLTER), were calculated and statistically analyzed for the two groups. Results: In univariate analysis, DC was a statistically significant predictor of TM (Log rank test p = 0.007). Furthermore after Cox regression analysis adjusted for LVEF, fQRS, NSVT episodes >1/24 hours, VPBs > 240/24 hours, mean Heart Rate, SDNN, and QTc (24 hour HOLTER), DC remained an important and independent TM predictor with Hazard Ratio: 0.862 (p = 0.01) 95% CI: 0.764�C0.973. A cut off point of DC http://www.selleckchem.com/products/dabrafenib-gsk2118436.html and short term follow up, DC was an important and independent predictor of TM. Further evaluation of the reduced DC of heart rate in a larger population with longer follow up is needed. O120 ATRIAL SENSING PERFORMANCE OF ICD LEADS WITH FLOATING ATRIAL DIPOLE Schirdewan A 1 ; Safak E 1 ; Schmitz D 2 ; Konorza T 3 ; Wende C 4 , on behalf of the Linoxsmart S DX Master Study Investigators 1 Charit�� Berlin , 2 Elisabeth Hospital Essen , 3 University Hospital Essen , 4 Marien Hospital Papenburg (Germany) Purpose: In this clinical investigation the atrial sensing quality of the single-coil ICD lead Linoxsmart S DX has been investigated. This http://www.selleck.cn/products/z-vad-fmk.html ICD lead has an additional floating atrial dipole which enables the detection http://www.selleckchem.com/products/sch772984.html of right atrial signals. Therefore IEGM-recording and statistics of the atrium in a single chamber ICD system can be provided. Methods: The Linoxsmart S DX ICD lead has been implanted with a Lumax VR-T 540 DX ICD of BIOTRONIK in 116 patients in 7 European countries. Atrial sensing was investigated at pre-hospital discharge, 1, 3 and 6 month follow-up. The patients were asked to take three body positions: lying dorsal and normal breathing, sitting and palms pressing together, and sitting with Jendrassik manoeuvre. The atrial sensing performance was observed in all three positions. The atrial senses were analyzed using the respective IEGMs. Results: In 1074 out of 1163 atrial sensing tests, appropriate atrial sensing performance was determined by the investigator. This results in a rate of appropriate atrial sensing of 92.3%. ? Appropriate atrial sensing Under-sensing Over-sensing Rate of appropriate atrial sensing Lying dorsal, normal breathing 364/388 11/388 13/388 93.8% Sitting, palms together 354/388 14/388 20/388 91.2% Sitting, Jendrassik Manoeuvre 356/387 12/387 20/387 92.0% Total 1074/1163 37/1163 53/1163 92.3% In six patients necessary ICD lead repositionings were successfully performed. Conclusion: This clinical investigation showed that the ICD lead Linoxsmart S DX with an additional floating atrial dipole provides an appropriate atrial sensing rate of 92.3%.