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Sponsor's Role: The funding sources had no role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript. ""To evaluate the efficacy of a municipality-led walking program under the Japanese public Long-Term Care Insurance Act to prevent mental decline. Randomized controlled http://www.selleckchem.com/products/smoothened-agonist-sag-hcl.html trial. The city of Takasaki. One hundred fifty community members aged 72.0?��?4.0 were randomly divided into intervention (n?=?75) and control (n?=?75) groups. A walking program was conducted once a week for 90?minutes for 3?months. The program encouraged participants to walk on a regular basis and to increase their steps per day gradually. The intervention was conducted in small groups of approximately six, so combined benefits of exercise and social interaction were expected. http://www.selleck.cn/products/SP600125.html Cognitive function was evaluated focusing on nine tests in five domains: memory, executive function, word fluency, visuospatial abilities, and sustained attention. Quality of life (QOL), depressive state, functional capacity, range of activities, and social network were assessed using questionnaires, and motor function was evaluated. Significant differences between the intervention and control groups were shown in word fluency related to frontal lobe function (F(1, 128)?=?6.833, P?=?.01), QOL (F(1,128)?=?9.751, P?=?.002), functional capacity including social interaction (F(1,128)?=?13.055, P? http://www.selleckchem.com/products/epz015666.html P?=?.002). No significant differences were observed in other cognitive tests. Walking programs may provide benefits in some aspects of cognition, QOL, and functional capacity including social interaction in elderly community members. This study could serve as the basis for implementation of a community-based intervention to prevent mental decline. ""To assess the safety and long-term results of hepatic resection of colorectal liver metastases (CLM) in older adults. Case�Ccontrol. Single liver and multivisceral transplant center. Individuals with CLM: 32 aged 70 and older (older group) and 32 younger than 70 (younger group) matched in a 1:1 ratio according to sex, primary tumor site, liver metastases at diagnosis, number of metastases, maximum tumor size, infiltration of cut margin, type of hepatic resection, and hepatic resection timing. Postoperative complications and survival rates. There was no significant difference in preoperative clinical findings between the two study groups. The incidence of cumulative postoperative complications was similar in the older (28.1%) and younger (34.4%) groups (P?=?.10). One-, 3-, and 5-year disease-free survival rates were 57.6%, 32.9%, and 16.4%, respectively, in the younger group and 67.9%, 29.2%, and 19.5%, respectively, in the older group (P?=?.72). One-, 3-, and 5-year participant survival rates were 84.1%, 51.9%, and 33.3%, respectively, in the older group and 93.