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The complete remission (CR) rate was 91% in Burkitt's lymphoma and 86% in mature B-ALL. OS and EFS at 7?yr were of 88% and 83%, respectively, for Burkitt's lymphoma, while the OS for mature B-ALL was 90% in adolescents, 71% in younger adults, and only 46% in older patients. The unfavourable outcome in the older population was attributed to a high incidence of infections and CNS relapses. Similarly, rituximab was incorporated into chemotherapy regimen http://www.selleckchem.com/products/ch5424802.html for adolescents and adults with CD20-positive B-precursor ALL. The effect of rituximab during induction and consolidation chemotherapy has been studied in CD20-positive Philadelphia-negative B-precursor ALL in the GMALL study 07/2003. Eight standard doses of rituximab were administered (one before each induction courses and one before each of the six consolidation cycles). In http://www.selleck.cn/products/Verteporfin(Visudyne).html standard-risk patients, there was no difference in terms of CR, early death, and failure between the patient who received rituximab and those who did not. However, MRD decreased in faster in the group with rituximab showing achievement of molecular remission (MRD? http://www.selleckchem.com/products/VX-770.html and low blood pressure. Severe potential adverse events included life-threatening anaphylaxis, and tumour lysis syndrome in highly proliferative disease, occurring within 12�C24?h after the first infusion of rituximab. Hepatitis B reactivation with fulminant hepatitis, hepatic failure and death in chronic carriers, severe mucositis, and progressive multi-focal leuko-encephalopathy, were also reported as serious events associated with rituximab administration [32, 33]. Prolongation of neutropenia and hypogammaglobulinemia leading to serious infections were also described [34].