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Just two articles deal with the clinical issues of: (i) the value of HistoScanning for targeted biopsies;[5] and (ii) the prediction of a negative margin in prostatectomy http://www.selleckchem.com/products/CP-673451.html patients.[6] The current article by De Connick et?al.[7] shows a potential role for HistoScanning in selecting patients in whom prostate biopsies are necessary. To date, we are generous in the decision-making for a biopsy in the case of an elevated prostate-specific antigen and/or positive digital rectal examination, and are willing to rebiopsy patients in whom biopsies were negative, but there is a persisting suspicion. Therefore, an objective tool to decide whether or not to biopsy or to avoid biopsy is required. The authors concluded that in the case of a total lesion volume of http://www.selleckchem.com/products/rxdx-106-cep-40783.html biopsy compared with a random biopsy was described in the examined patients. The better per core detection rate for the PHS-guided biopsies is an interesting result. However, one might question if the expense alone of such a technique can justify its use, and if additional cases of prostate cancer will be detected that might otherwise have not been detected by random biopsy. In my eyes, the question of whether HistoScanning can securely avoid biopsies cannot be answered by the present study. The number of patients is relatively low and the follow-up time is not long enough. The ideal setting to obtain the real negative predictive value would be in patients who undergo a cystoprostatectomy. Nevertheless, the authors can be congratulated for initiating the study to shed more light on the potential clinical value of HistoScanning. Finally, HistoScanning has one thing in common with most of the other innovative imaging methods, such as multiparametric magnetic resonance imaging, elastography, computerized transrectal ultrasound or contrast-enhanced ultrasound: data are sparse, and multicentric studies to show the real impact of these methods on the patients are missing. None declared. ""A 41-year-old man was diagnosed with a glomus tumor of the kidney, which was incidentally found by ultrasonography. Partial https://en.wikipedia.org/wiki/Crotamiton nephrectomy revealed a 10-mm encapsulated mass. We diagnosed it as a glomus tumor using morphological and immunohistochemical stains. Glomus tumors represent less than 2% of all soft tissue tumors. They most often occur in the extremities, typically in the subungual region of the fingers. Glomus tumors arising in the genitourinary regions are extremely rare. The present case is the first reported in Japan. A 41-year-old male office worker had previously been diagnosed with leukoderma. He had visited NTT West Osaka Hospital (Osaka, Japan) to undergo a complete medical check-up. Abdominal ultrasonography showed a 10-mm isoechoic mass in the right kidney.