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In this regard, several in vitro studies have demonstrated the ability of LDF to completely http://www.selleckchem.com/PD-1-PD-L1.html remove malignant cells [11, 23-26]. In agreement with these reports, several clinicians as well as recent guidelines from the Consensus Conference on Autologous Transfusion and National Institute for Health and Clinical Excellence have recommended the supplementation of LDF to IBS during cancer surgery [27-29]. Moreover, our previous in vitro study showed that LDF markedly reduced the risk for reintroduction of malignant cells [12]. A recent study also reported that IBS with LDF substantially reduced the risk of tumor cell reintroduction during the LT in recipients with nonruptured HCC tumors [13]. In our study, we present the first long-term results for a large number of LT recipients with HCC using IBS with LDF. Our study shows that recurrence-free survival rates do not differ between the two groups (Fig.?2). Filtering the processed RBCs with a LDF may significantly decrease the amount of cancer cells and thus reduce or eliminate the risk of cancer cell dissemination. Based on these results, it seems safe to use IBS with LDF during LT in recipients with HCC. There are some limitations to our study. First, we analyzed the data of Seoul National University hospital, which had a similar number of patients, but they were not randomized. The pathologic maximum tumor size of group 2 was larger than that in http://www.selleckchem.com/products/Adriamycin.html group 1, but the proportion of microvascular invasion in group 1 was higher than that in group 2. Second, transfusion criteria between two centers were not same. The transfusion criteria of RBCs, FFP, and platelet concentrate in group 1 was http://www.selleck.cn/products/MK-1775.html that in group 2 was