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In order to meet their anabolic requirements and proficiently multiply within hepatocytes, these parasites must scavenge host cell nutrients that they cannot synthesize. Furthermore, the incompetence of Plasmodium to store host molecules necessitates a constant supply of nutrients to the parasite. To this end, the choice of hepatocytes in the mammalian host may stem from the unique metabolic properties of these cells. Compared with other cells, hepatocytes are particularly proficient at internalizing transport proteins (e.g. transferrin, lipoproteins) via specific surface receptors and at metabolizing many compounds http://en.wikipedia.org/wiki/MYO10 (e.g. lipids, purines, glucose) in large quantities (Morgan and Baker, 1986; Pels Rijcken et?al., 1993; Klover and Mooney, 2004; Nguyen et?al., 2008). The nutritional requirements of Plasmodium must be complex, because even rich media do not support the multiplication of parasites maintained in an axenic environment (Jayabalasingham et?al., 2010). This observation implies that an intracellular niche is necessary to provide the parasite with a plethora of essential host cell factors during the trophic http://www.selleckchem.com/products/bay80-6946.html phase. The important role of the host cell in parasite growth is exemplified by the essentiality of the parasite protein UIS3 located at the PV membrane, which specifically interacts with the host liver-fatty acid binding protein (L-FABP), the main carrier responsible for the delivery of fatty acids to cytoplasmic compartments. The interaction between UIS3 and L-FABP may be necessary to supply the parasite with host fatty acids (Mikolajczak et?al., 2007). We showed that the parasite is able to transform its PV into a highly permeable compartment (Bano et?al., 2007). Open pores http://www.selleckchem.com/products/poziotinib-hm781-36b.html across the PV membrane interconnect the host cytoplasm and the vacuolar spaceand allow the passive diffusion of small molecules