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For example, according to data in Table 3, 54.2% of the patients with rN0 were reclassified as LODDS1, and 36.9% as LODDS2, 7.2% as LODDS3, and 1.7% as LODDS4. The difference in survival among patients in different LODDS classifications was significant. The similar phenomenon could also be observed for other patients with the ratio of nodes metastasis less than 0.2. However, it is important to note that, in the present study, patients with the ratio of nodes metastasis more than 0.8 (including 1) were not reclassified into different LDDOS groups. Nonetheless, it does not mean the LODDS system is not superior to the rN classification for these patients. The explanation is that, first, the scatter plots of the relationship between http://www.selleckchem.com/products/BIBF1120.html LODDS and the ratio of nodes metastasis demonstrated that the ratio of nodes metastasis increased slower than LODDS did for patients with the ratio of nodes metastasis more than 0.8. Second, if we hypothesis that both the 2 patients have the ratio of nodes metastasis equal to 1, and patient A has 4 positive lymph nodes of 4 lymph nodes retrieved and patients B has 20 positive lymph nodes of 20 lymph nodes retrieved, then do they have a same prognosis? Intuitively, patient A has a better prognosis than patient B. Patient A has less http://www.selleckchem.com/products/Metformin-hydrochloride(Glucophage).html nodes retrieved and, consequently, has a lower LODDS value (or lower LODDS classification) than patient B, indicating a better prognosis. This phenomenon also can be observed for patients with other ratio values of nodes metastasis. Last, Wang et al26 studied 24,477 patients with stage III colon cancer (node-positive cancers) and found that patients with LNR4 could be classified into LODDS4 (61.4%) and LODDS5 (38.4%). The survival in these 2 groups was significantly different (5-year survival, 33.5% vs 23.3%, P http://www.selleck.cn/products/carfilzomib-pr-171.html prognostic assessment provided by the LODDS classification is similar to that provided by the rN classification for patients with a ratio of nodes metastasis more than 0.2 and less than 0.8, because there was a closed linear correlation between the value of LODDS and ratio of nodes metastasis as shown in Figure 2B. Thus, we considered that the superiority of the LODDS classification to the rN classification might mainly because of its potential of discriminating patients with the same ratio of nodes metastasis but different survival. For further analyzing, we compared overall survival rates among different pN, rN, and LODDS classifications patients according to the total number of nodes retrieved.