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FR0365 Bone Microstructure During and After Lactation.?shild Bj?rnerem*1, Ali Ghasem-Zadeh2, Thuy Vu3, Ego Seeman2. 1Department of Community Medicine, University of Troms?, Norway, 2Austin Health, University of Melbourne, Australia, 3Endocrine Centre, Austin Health, University of Melbourne, Australia Estrogen deficiency increases bone turnover and bone loss. Lactation is an estrogen deficient state believed to be associated with reversible bone loss. As bone loss assessed using DXA may partly be the result of changes in marrow composition, we assessed the effects of lactation on volumetric bone mineral density (vBMD) and microarchitecture from baseline 14.6 days (2-25) after delivery, with follow-up during 5.2 months (2-7) of breastfeeding, and with the third measurement more than 6 months after weaning in 82 women aged 20-42 years. Total, cortical and trabecular vBMD, cortical and http://www.selleckchem.com/products/Everolimus(RAD001).html trabecular cross-sectional area (CSA), cortical and trabecular thickness, and trabecular number were measured at the distal tibia and radius using high-resolution 3-D peripheral quantitative computed tomography (HR-3D-pQCT XtremeCT; Scanco Medical, Switzerland). During lactation, tibia total and cortical vBMD diminished by 0.6 and 0.3% at distal tibia (p http://www.selleckchem.com/products/PD-0332991.html by 5.9 and 4.5% and trabecular number diminished by 4.4 and 2.1% at tibia and radius, respectively (all p http://www.selleck.cn/products/Bortezomib.html trabecular vBMD. Lactation may cause a deleterious effect on cortical structure as cortical bone loss was not completely restored after weaning in humans. Disclosures: ?shild Bj?vnevem, None. FR0368 Estradiol Replacement Therapy Lowers Serum Sclerostin Levels in Postmenopausal Women.Faryal Mirza*1, Pamela Taxel1, Yun Ey Chung2, Sandra Jastrzebski3, Lawrence Raisz1, Joseph Lorenzo1. 1University of Connecticut Health Center, USA, 2Univ. of Connecticut Health Center, USA, 3Univ of Connecticut Health Center, USA Purpose: Sclerostin is a negative regulator of Wnt signaling and bone formation. We previously reported that serum estrogen levels inversely correlate with serum sclerostin levels in postmenopausal women.