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Out of 56 (34.1%) accepted lung donors, 50 transplants were performed at our center, 23 from standard criteria donors versus 27 from extended criteria donors. There were no significant differences http://www.selleckchem.com/products/PD-0332991.html in hospital outcome and in early survival between lung recipients from both donor groups. Lung acceptance rate (34.1%) in our donor network is 10�C20% higher than reported figures. The number of lung transplants in our center doubled by accepting extended criteria donors. This policy did not negatively influence our results after lung transplantation. Lung transplantation is an effective treatment modality for selected patients suffering from any form of end-stage pulmonary disease [1]. As a result of the widespread success of lung transplantation, there is a persistent organ shortage with a percentage of patients not surviving the waiting period as their prospects on the thoracic waiting list are governed by the chance of receiving an organ in time [2]. Only about 15% of the multiple organ donors (MODs) have lungs suitable for transplantation when adhering to standard donor criteria [3]. In a recent analysis from the California Transplant Donor Network, more than 85% of the lungs were rejected for different reasons [4]. Previously, a lung donor was considered ideal when the following criteria were met: age ?300?mmHg [on fraction of inspired http://www.selleck.cn/products/Bortezomib.html oxygen (FiO2)?=?1.0 and positive end expiratory pressure (PEEP)?=?5?cm H2O], smoking history http://www.selleckchem.com/products/Everolimus(RAD001).html donor criteria were arbitrarily chosen based on broad clinical impressions rather than solid medical evidence [6]. Meanwhile, experienced centers have liberalized their donor criteria in the last decade. In a recent multicenter study from Canada, a lung utilization rate of 23% was reported [7]. In Eurotransplant, out of 2003 deceased donors in the year 2008, 508 (25.3%) served as lung donors [8]. This percentage is still much lower compared with other solid organs (kidney: 91.5%; liver: 77.3%; heart: 29.1%). Numerous studies have previously reported that lungs from so called extended criteria donors, not matching these standard criteria, can be transplanted successfully [9�C18]. Two reports, however, demonstrated a negative effect on hospital outcome but not on long-term survival [15,18]. A review paper on the subject recently argued for further cautious relaxation of the once-strict guidelines on deceased lung donor acceptability criteria, especially with respect to older donor age [19].