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9 Distant metastases develop in 10% to 15% of patients, most commonly to the liver (20% to 30%) and lung (10% to 20%).42 In contrast, brain metastases from CRC are rare, occurring in only 4% of cases43 (Table 5) and are concomitant with lung metastases in 55% to 85% of patients7 and liver metastases in up to 75%.44 Postmortem studies have shown that an additional http://www.selleckchem.com/products/BI-2536.html 2% to 3% of patients who die of colorectal cancer will harbor occult brain metastases at autopsy.42 The cerebellum is the site of intracranial metastasis in up to 55% of affected CRC patients,42, 43 which may explain the high prevalence of gait abnormalities reported. Wronski et al42 have also reported infratentorial masses in 6 of 73 (8.2%) patients with CRC brain metastasis who presented with obstructive hydropcephalus. The bDFI between diagnosis of CRC and discovery of brain metastasis has been shown to correlate with subsequent survival.45 For CRC, the bDFI ranges from 22.6 to 27.6 months (Table 5), which is considerably longer than for other GI cancers (range, 5.6-30 months)5, 46 and lung cancer (average 4 months) but shorter than breast cancer (average 3 years).45 Hammoud et al45 investigated http://www.selleckchem.com/products/Cyclopamine.html factors affecting bDFI for CRC and identified Dukes' stage and treatment status of extracerebral metastatic disease.45 Median bDFIs in patients with Dukes' stage http://www.selleck.cn/products/gsk126.html B (n = 28), C (n = 48), and D CRC (n = 24) was 40 months, 26 months, and 8 months, respectively (P