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MRSI spectra were examined and scored as healthy or cancerous. The change in cancerous volumes over time was evaluated. Of the 10 patients enrolled, nine patients completed the entire study. One patient withdrew after 3 months because of drug-related toxicity. Because a significant decrease in citrate and polyamines on MRSI spectra was noted at 1 month compared with baseline, healthy tissue appeared to be more like cancer and thus created a false impression that the cancer had grown after 1 month. To reduce this bias, comparisons were made between the 1-month and 6-month scans. The median MR cancer volumes at 6 months http://www.selleckchem.com/products/PD-0325901.html and 3 months were 100% and 101% of the 1-month value, respectively. Three of the nine patients had a 30�C45% decrease in cancer volume at 6 months relative to 1-month measures. Of the others, two had no change in cancer volume and four had an increase (range 65�C167% of the 1-month value). The median cancer volume (range) at baseline was only 0.5 (0.1�C5.6) mL. The inclusion of only men with low volume disease may have limited our ability to accurately assess response rates after dutasteride due to the background effects on normal prostate metabolism. Despite this, one-third of patients had a 30�C45% reduction in cancer volume at 6 months. Future studies including men with larger volume disease may enable estimates of response rates to be made http://www.selleck.cn/products/JNJ-26481585.html more accurately. ""Study Type �C Diagnosis (case series) Level of Evidence?4 What's known on the subject? and What http://www.selleckchem.com/products/epz-6438.html does the study add? Benign prostatic hyperplasia is the most common symptomatic disorder of the prostate and its severity varies greatly in the population. Various methods have been used to estimate prostate volumes in the past including the digital rectal examination and ultrasound measurements. High-resolution T2 weighted MRI can provide accurate measurements of zonal volumes and total volumes, which can be used to better understand the etiology of lower urinary tract symptoms of men. To use ability of magnetic resonance imaging (MRI) to investigate age-related changes in zonal prostate volumes. This Institutional Review Board approved, Health Insurance Portability and Accountability Act-compliant study consisted of 503 patients who underwent 3?T prostate MRI before any treatment for prostate cancer. Linear regression analysis showed positive correlations between WP, CG volumes and patient age (P
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