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We found stable VA improvements and a low rate of amblyopia recurrence in both treatment modalities. The current findings agree with those of Steele et?al. (2006), who also reported a low recurrence rate after optical treatment of anisometropic amblyopia, and those of Iacobucci et?al. (2001), who reported a low rate of recurrence after treating anisometropic and strabismic amblyopia with Bangerter filters. However, http://www.selleck.cn/products/ON-01910.html there are no long-term data after completion of amblyopia treatment with spectacles alone or in combination with Bangerter filters. Researchers evaluating amblyopia treatment with patching have reported varying results in VA stability (Scott & Dickey 1988; Kutschke et?al. 1991; Leiba et?al. 2001; Ohlsson et?al. 2002; Rutstein & Corliss 2004). The PEDIG found long-term maintenance of the VA improvement when patients were treated with atropine or patching (Pediatric Eye Disease Investigator Group 2008). That study also reported better visual outcomes in amblyopic children younger than 5?years. Thus, one explanation for the good results in the current study may be the young patient age (mean, 4.5?years in both groups) in the randomized trial. The baseline VA was the best VA with or without spectacle correction, because 43% of the http://www.selleckchem.com/products/loxo-101.html children had decreased VA with spectacles owing to their inability to relax accommodation. These young children wore spectacles for the first time at the baseline examination and had difficulty co-operating and determining the effect of a minus lens over the spectacles. Therefore, we might have underestimated the VA in some children http://www.selleckchem.com/products/bms-911543.html at baseline. However, excluding the children with a baseline VA determined without correction and with resolved amblyopia at 0.5?month did not alter the statistical results regarding the main outcome measure, i.e., the median change in VA of the amblyopic eye after 2?years. At the follow-up visits when the children were more adapted to the spectacles and more confident with the examination, we placed a minus lens over the spectacles. A fixed-filter density of 0.3, which is thought to degrade the VA of the fellow eye to about 0.52 logMAR, was used for all children in the current study. Therefore, we evaluated whether spectacles plus a Bangerter filter were more efficient than spectacles alone in children with mild-to-moderate amblyopia (VA?