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[63] Clinical signs are more common in cats than dogs because of the frequency of feeding fish-based diets to cats, and include anorexia, ataxia, blindness, and seizures.[64] Clinical signs of mercury toxicity in dogs include neurologic dysfunction, gastrointestinal signs including vomiting and death.[65] Hypervitaminosis is a concern with fish oil supplements such as cod liver oil, especially when they are supplemented at high dosages. Fat-soluble vitamins, especially vitamins D and A, are more of a concern than water-soluble vitamins because most water-soluble vitamins do not accumulate in tissue. There have been no reports in humans of vitamin D or A toxicity associated with fish oil supplementation and although the potential for toxicity exists, it is low.[45, 66] Even at a high dosage of supplementation such as 220?mg fish oil per kilogram body weight it would be difficult to reach the safe upper limit http://www.selleckchem.com/products/lee011.html for vitamins D and http://www.selleck.cn/products/AZD6244.html A. The safe upper limits for a 10?kg dog are 14.6?��g cholecalciferol (584 international units) and 11,804 retinol equivalents of vitamin A.[28] Overall, with the diversity of therapeutic uses for fish oil, the benefits of fish oil intake likely outweigh the risks of toxin exposure and nutrient excess. Veterinarians should inquire about the mercury and toxin concentrations of fish oil supplements before prescribing them to clinical patients. Contacting the manufacturer may be necessary to ascertain this information. Although weight gain is not a commonly noted adverse effect of omega-3 fatty acid supplementation, the calories that oil contains should be a concern. Fat is the most energy dense nutrient when compared with protein or carbohydrate, and each gram of oil contains about 9?kcal.[67] One teaspoon (5?ml) of oil contains about 42?kcal.[67] Weight gain could occur when large dosages of omega-3 fatty acids are recommended, such as for dogs with osteoarthritis or neoplastic disease. Published recommendations for dogs with neoplastic disease include adding 12�C20 fish oil capsules per day for a 10?kg dog.[48] This represents 108�C180?kcal of fish oil per day http://www.selleckchem.com/products/bmn-673.html whereas the resting energy requirements for a 10?kg dog are