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03, 95% CI 1.63�C5.65, P? http://www.selleck.cn/products/Methazolastone.html in different ethnic groups.[24, 31] The reported prevalence of sarcopenia ranged from 8% to 40% by using different diagnostic instruments, different age and living conditions of the study participants in each study.[5, 32] The prevalence of sarcopenia was 30.9% in the present study. It was similar to two other cohort studies in Taiwan.[15, 26] One cohort study had a sample of 761 ethnic Taiwanese older adults (354 men and 407 women) who lived in Taichung City, central Taiwan, where skeletal muscle mass was measured using dual-energy X-ray absorptiometry, and the prevalence of sarcopenia was 21% in participants aged 75 years and older.[15] Another cohort study in northern Taiwan included 302 individuals (157 men and 145 women) aged 65 years and older, and the prevalence of sarcopenia (estimated by BIA) was 23.6% in men.[26] The prevalence of sarcopenia has been reported to rise with older age[5, 6] and comorbidity,[8] which is compatible with results of the present study. In the recent EPIDOS cohort study, sarcopenia http://www.selleckchem.com/products/ABT-737.html was not shown to be associated with cognitive impairment in elderly women.[9] Some previous reports have shown that only physical performance or muscle strength,[33] but not muscle mass, was associated with cognitive function.[34] On the contrary, some studies supported that changes in body composition (muscle mass, fat mass or lean mass) were closely related to cognitive impairment.[35] In the present study, both cognitive impairment and depressive symptoms were significantly associated with sarcopenia, which deserves further investigation. However, several possible mechanisms might be helpful to explain the association of cognitive impairment and sarcopenia. First, cognitive impairment usually led to less physical activity (bed rest or sedentary lifestyle) and inadequate dietary intake, which could trigger excessive muscle loss in older adults.[10] Second, a mechanism http://www.selleckchem.com/products/Nutlin-3.html commonly shared by sarcopenia and cognitive impairment was inflammation. Age-related chronic low-grade inflammation featured by the elevation of interleukin-6 and tumor necrosis factor-�� has also been reported as an important causative factor for the occurrence of sarcopenia[36, 37] and the development of cognitive impairment.[38] Third, excessive oxidative stress related to chronic diseases might also cause skeletal muscle wasting,[39] as well as sarcopenia.[40] Excessive oxidative stress also played a crucial role in neuronal degeneration and cognitive impairment.